Article

<i>TET1</i> and <i>TDG</i> suppress intestinal tumorigenesis by down-regulating the inflammatory and immune response pathways

2019-06-21

Abstract excerpt

<h4>Introduction</h4> Aberrant DNA methylation is frequently observed in colorectal cancer (CRC), but the underlying mechanisms are poorly understood. Ten-Eleven Translocation (TET) dioxygenases and DNA repair enzyme Thymine DNA Glycosylase (TDG) are involved in active DNA demethylation by generating and removing, respectively, novel oxidized cytosine species. Mutations of TET1 and TDG , and alterations of the...

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Literature Corpus work: cb4504de-299c-5e1e-91f3-4f2307778593
DOI: 10.1101/676445

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