Article

Notch dimerization contributes to maintenance of intestinal homeostasis by a mechanism involving HDAC2

2024-04-29

Abstract excerpt

A tri-protein complex containing NICD, RBPj and MAML1 binds DNA as monomer or, cooperatively, as dimers to regulate transcription. Mice expressing Notch d imerization- d eficient (DD) alleles of N otch1 and N otch2 (NDD) are sensitized to environmental insults but otherwise develop and age normally. Transcriptomic analysis of colonic spheroids uncovered no evidence of dimer-dependent target gene miss-regulatio...

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Literature Corpus work: 40446b20-4fb2-52e2-b20e-f0d971e33a9f
DOI: 10.1101/2024.04.26.591336

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