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Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

2025-02-06

Abstract excerpt

Extrachromosomal DNAs (ecDNAs) are large, acentric, circular DNA molecules that occur pervasively across many human cancers. EcDNA can drive tumor formation and evolution, contribute to drug resistance, and associate with poor patient survival outcomes. Beyond mediating high copy numbers, the circular topology and dynamic conformational changes of ecDNA disrupt topological domains and rewire regulatory networks, t...

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Literature Corpus work
31cf16a0-40c8-5b5f-a251-ede4c008481e
DOI
10.1101/2025.02.01.636064
Open publication

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Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3DDOI 10.1101/2025.02.01.636064
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