MLH1 −93G/A Polymorphism: Its Role in Colorectal Cancer Progression and Metastasis

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) is a prominent cause of global cancer mortality, with approximately 10–16% of diagnosed individuals carrying a pathogenic mutation in a cancer-susceptibility gene. The mismatch repair (MMR) mechanism is a critical pathway for preserving genomic integrity, and MLH1, encoding MutL homolog 1, is a key component of this system. The − 93G/A (rs1800734) pol...

Topics

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• Adaptor Proteins, Signal Transducing
• Colorectal Neoplasms
• Databases, Bibliographic
• Microsatellite Instability
• MutL Protein Homolog 1
• Odds Ratio
• Publication Bias
• Risk

Identifiers and source

Literature Corpus work

cb5cf755-9f31-5bba-a162-43ce89327254

DOI

10.21203/rs.3.rs-10167465/v1