The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer.

doi:10.1186/s13148-017-0326-6

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Article

The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer.

Clinical epigenetics - 1 Jan 2017

Savio Andrea J, Mrkonjic Miralem, Lemire Mathieu, Gallinger Steven, Knight Julia A, Bapat Bharat

Abstract excerpt

BACKGROUND: Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tumours due to mutation or, more commonly, due to DNA methylation of its promoter CpG island. A single nucleotide polymorphism (SNP) in the CpG island of MLH1 (MLH1-93G>A or rs1800734) is...

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PMID: 28293327
DOI: 10.1186/s13148-017-0326-6
PMCID: PMC5345264

Genes

MLH1

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