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Article

MLH1-93G > A is a risk factor for MSI colorectal cancer.

Carcinogenesis - 1 Aug 2011

Whiffin Nicola, Broderick Peter, Lubbe Steven J, Pittman Alan M, Penegar Steven, Chandler Ian, Houlston Richard S

Abstract excerpt

The -93G > A (rs1800734) polymorphism within the core promoter region of the MutL homolog 1 (MLH1) gene has recently been proposed as a low penetrance variant for colorectal cancer (CRC). We evaluated the significance of rs1800734 on CRC risk by genotyping 10 409 CRC cases and 6965 controls. The per allele odds ratio (OR) for all CRC-associated MLH1-93G > A was 1.06 (P = 0.037). Using a subset of 3132 cases with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21565826
DOI: 10.1093/carcin/bgr089

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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