Article

The Spread of Interferon-γ in Melanomas is Highly Spatially Confined, Driving Non-Genetic Variability in Tumor Cells

2023-01-27

Abstract excerpt

Interferon-γ (IFNγ) is a critical anti-tumor cytokine that has varied effects on different cell types. The global effect of IFNγ in the tumor depends on which cells it acts upon and the spatial extent of its spread. Reported measurements of IFNγ spread vary dramatically in different contexts, ranging from nearest-neighbor signaling to perfusion throughout the entire tumor. Here, we apply theoretical considerations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb593661-3e1a-50b2-a7b2-ad553d4a9e53
DOI: 10.1101/2023.01.26.525713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Spread of Interferon-γ in Melanomas is Highly Spatially Confined, Driving Non-Genetic Variability in Tumor CellsDOI 10.1101/2023.01.26.525713Read

Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaSemantic proximity Read

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanomaSemantic proximity Read

Immune and non-immune cell fencing of tumor cells is a widespread and functionally relevant spatial pattern in solid cancersSemantic proximity Read

Dynamical modelling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneitySemantic proximity Read

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaSemantic proximity Read

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor CharacteristicsSemantic proximity Read

Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsivenessSemantic proximity Read

Spatially Informed Gene Signatures for Response to Immunotherapy in MelanomaSemantic proximity Read

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humansSemantic proximity Read

Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune NetworksSemantic proximity Read

Effector T Cells under Hypoxia have an Altered Transcriptome Similar to Tumor-Stressed T Cells Found in Non-Responsive Melanoma PatientsSemantic proximity Read

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cellsSemantic proximity Read