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Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanoma

2023-12-08

Abstract excerpt

High-dimensional, spatial single-cell technologies such as CyTOF imaging mass cytometry (IMC) provide detailed information regarding locations of a large variety of cancer and immune cells in microscopic scales in tumor microarray (TMA) slides obtained from patients prior to immune checkpoint inhibitor (ICI) therapy. An important question is how the initial spatial organization of these cells in the tumor microenv...

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Literature Corpus work
71270375-3ae0-527c-9b12-5aba0efd5901
DOI
10.1101/2023.12.06.570410
Open publication

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Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaDOI 10.1101/2023.12.06.570410
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