Article

Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsiveness

2022-02-09

Abstract excerpt

<title>Abstract</title> <p>While immune checkpoint-based immunotherapy (ICI) shows spectacular clinical results in cancer patients, only a subset of the these respond favorably to such treatment. Response to ICI is dictated by the integration of complex networks of cellular interactions between malignant and non-malignant cells. Although new insights into the mechanisms that modulate the pivotal anti-tumoral acti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d294135-1277-50e0-9f83-01ef6c1042c4
DOI: 10.21203/rs.3.rs-1236531/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsivenessDOI 10.21203/rs.3.rs-1236531/v1Read

Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell–Cell Interactions That Predict Immunotherapy ResponseSemantic proximity Read

Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain MetastasesSemantic proximity Read

Spatial organization and stochastic fluctuations of immune cells impact clinical responsiveness to immune checkpoint inhibitors in patients with melanomaSemantic proximity Read

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaSemantic proximity Read

Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanomaSemantic proximity Read

Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanomaSemantic proximity Read

Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapySemantic proximity Read

Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imagingSemantic proximity Read

A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade TherapiesSemantic proximity Read

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibitionSemantic proximity Read

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasisSemantic proximity Read

Linking Transcriptomic and Imaging Data Defines Features of a Favorable Tumor Immune Microenvironment and Identifies a Combination Biomarker for Primary MelanomaSemantic proximity Read