Article

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells

2026-04-05

Abstract excerpt

We generated interferon signaling reporters in human and mouse melanoma cells and observed heterogeneity in interferon responses among cells in the same tumors. This was marked by inflamed regions within primary tumors that contained increased numbers of interferon-expressing macrophages/monocytes and elevated type I interferon signaling in melanoma cells. Melanoma cells that expressed GFP-Interferon stimulated ge...

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Literature Corpus work: 3af49cf5-0b0e-5d9e-b2a0-72b623608545
DOI: 10.64898/2026.04.01.715921

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