Article

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans

2024-09-19

Abstract excerpt

<h4>Summary</h4> Immunotherapy leads to cancer eradication despite the tumor’s immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of human melanoma, to identify domains that facilitate immune response during immunotherapy. We identified crater-shaped pockets at the margins of zebrafi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 43916304-e734-5268-9e6c-54119c4e11f2
DOI: 10.1101/2024.09.18.613595

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humansDOI 10.1101/2024.09.18.613595Read

Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapySemantic proximity Read

Tertiary lymphoid structures improve immunotherapy and survival in melanoma.Semantic proximity Read

Immune organization in sentinel lymph nodes of melanoma patients is prognostic of distant metastasesSemantic proximity Read

Decoding melanoma-immune cell communication through spatially resolved ligand-receptor interaction analysesSemantic proximity Read

Unraveling the Single-Cell Spatial Landscapes of Melanoma Brain MetastasesSemantic proximity Read

Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application.Semantic proximity Read

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaSemantic proximity Read

Cellular interactions in the sentinel lymph node predict melanoma recurrenceSemantic proximity Read

Deciphering Melanoma Cell States and Plasticity with Zebrafish Models.Semantic proximity Read

Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanomaSemantic proximity Read

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cellsSemantic proximity Read

Monkeybread: A Python toolkit for the analysis of cellular niches in single-cell resolution spatial transcriptomics dataSemantic proximity Read