Article

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

2022-06-17

Abstract excerpt

<h4>ABSTRACT</h4> The noninflamed microenvironment in prostate cancer represents a barrier to immunotherapy. Genetic alterations underlying cancer cell-intrinsic oncogenic signaling have emerging roles in shaping the immune landscape. Recently, we identified Pygopus 2 ( PYGO2 ) as the driver oncogene for the amplicon at 1q21.3. Here, using transgenic mouse models of metastatic prostate adenocarcinoma, we found t...

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Literature Corpus work: b11fcced-540d-577a-b865-69742e4adef5
DOI: 10.1101/2022.06.16.496505

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