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Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

23 Jan 2025

Abstract excerpt

Prostate cancer is a common malignancy that in 5%-30% leads to treatment-resistant and highly aggressive disease. Metastasis-potential and treatment-resistance is thought to rely on increased plasticity of the cancer cells-a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create cellular heterogeneity. To understand the molecular basis of this...

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PMID: 39853587
DOI: 10.1002/ijc.35327

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