Article

ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities

2025-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically engineered mouse models, xenografts, and patient-derived organoids have each advanced mechanistic insight but are limited by genetic scope, scalability, or lack of immune context. To overcome these constra...

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Literature Corpus work: 3043d622-77b6-583f-ad58-6a3b3fb29f72
DOI: 10.1101/2025.11.16.688689

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