Article

A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasis

2026-03-27

Abstract excerpt

<h4>Summary</h4> Prostate cancer encompasses a spectrum of disease states driven by complex cellular heterogeneity. To delineate the transcriptional programs underlying lineage plasticity and metastasis, we constructed a comprehensive single-cell atlas of 128 patients, spanning localized, castration-resistant, and metastatic disease. Lineage plasticity was prevalent in localized disease, with subsets of tumor cel...

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Literature Corpus work: 7e2868f8-4be3-5cdb-b220-169b816a7388
DOI: 10.64898/2026.03.25.711335

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