Article

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasis

2026-05-11

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer encompasses a spectrum of disease states driven by complex cellular heterogeneity. To delineate the transcriptional programs underlying lineage plasticity and metastasis, we constructed a comprehensive single-cell atlas of 128 patients, spanning localized, castration-resistant, and metastatic disease. Lineage plasticity was prevalent in localized disease, with subsets of...

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Literature Corpus work: dc9467e5-afd0-57e8-9aaf-2b3e835216d0
DOI: 10.21203/rs.3.rs-9430776/v1

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