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Article

LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer

2 Jan 2025

Abstract excerpt

Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression, thereby shaping tumor heterogeneity and therapy response. In castration-resistant prostate cancer (CRPC), the intricacies behind androgen receptor (AR)-independent lineage plasticity remain unclear, leading to a scarcity of effective clinical treatments....

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Epigenetics and DNA Methylation
Genetic factors in colorectal cancer
Prostate Cancer Treatment and Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39743630
DOI: 10.1038/s41422-024-01025-z

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