Article

Single–gene knockout of RNLS or HIVEP2 are insufficient to protect β–cell spheroids from allo– and xeno–rejection

2025-08-02

Abstract excerpt

Type 1 diabetes can be cured by β–cell replacement in principle, yet recurrent autoimmunity and transplantation barriers rapidly destroy implanted cells. Genome–wide CRISPR screening by Cai et al . highlighted RNLS and HIVEP2 as candidate genes, but their value outside an autoimmune setting is unknown. Here, it was evaluated whether single-gene knockout of RNLS or HIVEP2 could similarly protect β-cell grafts agai...

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Identifiers and source

Literature Corpus work: 334856d4-17bd-5344-abda-9e3c9be6ad53
DOI: 10.1101/2025.07.30.667633

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