Article

Presenilin-2 interacts with Lamtor1 at late endosome/lysosome-endoplasmic reticulum contact sites to guard endolysosomal homeostasis

2025-11-12

Abstract excerpt

<title>Abstract</title> <p>Mutations in Presenilin-2 (PSEN2), a catalytic subunit of the γ-secretase complex, cause familial Alzheimer’s disease (AD). Beyond its role in β-amyloid generation, we hypothesized that PSEN2 also supports key cellular functions whose disruption may underlie neuronal vulnerability. We now demonstrate that PSEN2 in late endosomes/lysosomes (LE/Lys) specifically localizes at contact sites...

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Literature Corpus work: cb287962-eef3-596b-b058-775e12242d3d
DOI: 10.21203/rs.3.rs-8068059/v1

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