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Article

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.

Biochemical and biophysical research communications - 9 Mar 2007

Suzuki-Utsunomiya Kyoko, Hadano Shinji, Otomo Asako, Kunita Ryota, Mizumura Hikaru, Osuga Hitoshi, Ikeda Joh-E

Abstract excerpt

ALS2, the causative gene product for a number of recessive motor neuron diseases, is a guanine-nucleotide exchange factor for Rab5, and acts as a modulator for endosome dynamics. Recently, we have identified a novel ALS2 homolog, ALS2CL, which is highly homologous to the C-terminal half of ALS2. In this study, we investigate the molecular features of ALS2CL and its functional relationship with ALS2. A majority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17239822
DOI: 10.1016/j.bbrc.2006.12.229

Genes

ALS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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