Article

Proximity labeling reveals unique and shared interactomes of unmodified and pyroglutamate amyloid beta in human hippocampus in Alzheimer’s disease

2026-05-19

Abstract excerpt

<title>Abstract</title> <p>Amyloid plaques are a hallmark neuropathological feature of Alzheimer's disease (AD), composed of insoluble amyloid beta (Aβ) peptide. Aβ undergoes post-translational modifications that alter their biophysical properties, aggregation kinetics, and neurotoxicity, creating a heterogeneous pool of species that differentially affect AD pathogenesis. Pyroglutamate-modified Aβ (pEAβ) is a par...

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Literature Corpus work: f756af9c-9cec-5cbd-baef-54497d74f95a
DOI: 10.21203/rs.3.rs-9620660/v1

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