Article
Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage.
The Journal of biological chemistry - 1 Dec 2017
Williamson Rebecca L, Laulagnier Karine, Miranda André M, Fernandez Marty A, Wolfe Michael S, Sadoul Rémy, Di Paolo Gilbert
Abstract excerpt
Amyloid plaques, a neuropathological hallmark of Alzheimer's disease, are largely composed of amyloid β (Aβ) peptide, derived from cleavage of amyloid precursor protein (APP) by β- and γ-secretases. The endosome is increasingly recognized as an important crossroad for APP and these secretases, with major implications for APP processing and amyloidogenesis. Among various post-translational modifications affecting...
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