Article

NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C

2020-08-02

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both hydrolytic and signaling functions require precise regulation of lysosomal cholesterol content. In Niemann-Pick type C (NPC), loss of the cholesterol exporter, NPC1, causes cholesterol accumulation within lysosomes, leading to...

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Literature Corpus work: 2c78b80f-6fc2-5f3f-8759-fe8bc0d457cd
DOI: 10.1101/2020.08.02.233254

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