Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Review of the Familial Alzheimer’s Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1

9 Nov 2018

Abstract excerpt

PRESENILIN 1 (PSEN1) and PRESENILIN 2 (PSEN2) genes are loci for mutations causing familial Alzheimer's disease (fAD). However, the function of these genes and how they contribute to fAD pathogenesis has not been fully determined. This review provides a summary of the overlapping and independent functions of the PRESENILINS with a focus on the lesser studied PSEN2. As a core component of the γ-secretase complex,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Genetics and Neurodevelopmental Disorders
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30412492
DOI: 10.3233/jad-180656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Review of the Familial Alzheimer’s Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1PMID 30412492Read ↗

Identification of the role of presenilins beyond Alzheimer's disease.Semantic proximity Read ↗

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s diseaseSemantic proximity Read ↗

Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders.Semantic proximity Read ↗

Early-onset familial Alzheimer's disease in a family with mutation of presenilin 2 gene.Semantic proximity Read ↗

Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer's Disease.Semantic proximity Read ↗

Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease.Semantic proximity Read ↗

Alzheimer's Disease: An Updated Overview of Its Genetics.Semantic proximity Read ↗

Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene.Semantic proximity Read ↗

[Alzheimer's disease: basic aspects].Semantic proximity Read ↗

Early-onset familial Alzheimer's disease (EOFAD).Semantic proximity Read ↗

The presenilin genes: a new gene family involved in Alzheimer disease pathology.Semantic proximity Read ↗

The genetics of Alzheimer disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.