Article

Cell competition drives bronchiolization and pulmonary fibrosis.

2024-04-22

Abstract excerpt

<title>Abstract</title> <p>Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from the maladaptive differentiation of lung stem cells into bronchial epithelial cells rather than into alveolar type 1 (AT1) cells, which are responsible for gas exchange. Here, we report that healthy lungs maintain their stem cells through tonic Hippo and β-catenin signaling, which promote Yap/Taz degradati...

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Literature Corpus work: cb2400cf-2418-505c-8069-7413650f5f17
DOI: 10.21203/rs.3.rs-4177351/v1

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