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Article

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells.

Nature communications - 21 Jun 2018

Liu Yongqing, Siles Laura, Lu Xiaoqin, Dean Kevin C, Cuatrecasas Miriam, Postigo Antonio, Dean Douglas C

Abstract excerpt

A model of K-Ras-initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma. In hypoxic, Tgf-β1-rich interiors of adenomas, we show that adenoma cells divide asymmetrically to produce cancer-generating cells highlighted by epithelial mesenchymal transition and a CD44/Zeb1 loop. In these cells, Zeb1 represses the Smad inhibitor Zeb2/Sip1, causing Pten loss and launching...

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Identifiers

PMID: 29930325
DOI: 10.1038/s41467-018-04663-1
PMCID: PMC6013470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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