Article

A Tunable Pulmonary Organoid Model Demonstrates Compositionally Driven Epithelial Plasticity and Immune Polarization

2025-06-09

Abstract excerpt

<h4>Summary/Abstract</h4> Aberrant epithelial regeneration and immune remodeling are hallmarks of chronic lung diseases such as idiopathic pulmonary fibrosis (IPF), COPD, and post-viral syndromes. Yet how cellular context shapes these trajectories remains unresolved. We present a tunable, primary rat-derived lung organoid model that systematically varies immune, epithelial, and mesenchymal inputs to reveal how co...

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Literature Corpus work: cc757e98-17ce-5125-bdb5-3f12f6c306fe
DOI: 10.1101/2025.06.05.658120

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