Mechanosensitive Endothelial METTL7A Regulates Internal m ⁷ G mRNA Methylation and Protects Against Atherosclerosis

Abstract excerpt

<h4>BACKGROUND</h4> Internal N 7 -methylguanosine (m 7 G) is a recently identified chemical modification of mammalian mRNA and a component of the epitranscriptome. While the epitranscriptome plays a key role in regulating RNA metabolism and cellular function, the specific contribution of internal m 7 G to cardiovascular health and disease remains unknown. Atherosclerosis preferentially develops at sites where...

Topics

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• Aorta
• Atherosclerosis
• CpG Islands
• Endothelial Cells
• Endothelium, Vascular
• RNA modifications and cancer
• Spatio-Temporal Analysis
• Swine

Identifiers and source

Literature Corpus work

8875d596-16af-594f-ae59-192c72f98127

DOI

10.1101/2025.05.22.655328