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Article

Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 2008

Villeneuve Louisa M, Reddy Marpadga A, Lanting Linda L, Wang Mei, Meng Li, Natarajan Rama

Abstract excerpt

Diabetic patients continue to develop inflammation and vascular complications even after achieving glycemic control. This poorly understood "metabolic memory" phenomenon poses major challenges in treating diabetes. Recent studies demonstrate a link between epigenetic changes such as chromatin histone lysine methylation and gene expression. We hypothesized that H3 lysine-9 tri-methylation (H3K9me3), a key...

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Share to Chromobox Protein Homolog 5
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunologic Memory

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Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Identifiers

PMID: 18579779
DOI: 10.1073/pnas.0803623105
PMCID: PMC2449362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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