Article

Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease

2022-10-05

Abstract excerpt

<title>Abstract</title> <p>Itaconate, the product of the decarboxylation of cis-aconitate, regulates numerous biological processes. We and others have revealed itaconate as a regulator of fatty acid beta-oxidation, generation of mitochondrial reactive oxygen species and the metabolic interplay between resident macrophages and tumors. In the present study, we show that itaconic acid is upregulated in human non-alc...

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Literature Corpus work: cafd8247-db6f-51db-b88e-3d597566f418
DOI: 10.21203/rs.3.rs-2109910/v1

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