Article

4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

2022-12-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Pancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor 2 (Nrf2) in macrophages, itaconate is important in a series of inflammatory-associated diseases by anti-inflammatory and antioxidant properties. However, i...

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Literature Corpus work: 2c182409-8bb2-5a51-852b-ef793504190c
DOI: 10.21203/rs.3.rs-2355930/v1

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