Article

Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

2021-01-20

Abstract excerpt

Itaconate has recently emerged as a metabolite with immunomodulatory properties. We evaluated effects of endogenous itaconate and exogenous itaconate, dimethyl-, and 4-octyl-itaconate on host responses to influenza A virus infection. Infection induced ACOD1 (the enzyme catalyzing itaconate synthesis) mRNA in monocytes and macrophages, which correlated with viral replication and was abrogated by itaconate treatmen...

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Literature Corpus work: 846ccaed-c45a-51ca-b50e-a3c28a31f95b
DOI: 10.1101/2021.01.20.427392

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