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Itaconate family-based host-directed therapeutics for infections

16 May 2023

Abstract excerpt

Itaconate is a crucial anti-infective and anti-inflammatory immunometabolite that accumulates upon disruption of the Krebs cycle in effector macrophages undergoing inflammatory stress. Esterified derivatives of itaconate (4-octyl itaconate and dimethyl itaconate) and its isomers (mesaconate and citraconate) are promising candidate drugs for inflammation and infection. Several itaconate family members participate...

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PMID: 37261340
DOI: 10.3389/fimmu.2023.1203756

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