Article

SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice

2025-05-13

Abstract excerpt

<h4>SUMMARY</h4> Proper regulation of inflammatory responses is essential for organismal health. Dysregulation can lead to accelerated development of the diseases of aging and the aging process itself. Here, we identify a novel enzymatic activity of the mitochondrial sirtuin SIRT4 as a lysine deitaconylase that regulates macrophage inflammatory responses. Itaconate is a metabolite abundantly produced in activated...

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Literature Corpus work: c6f7653b-3689-513e-b1a1-523ca81bf088
DOI: 10.1101/2025.05.12.653532

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