Article

High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

2022-10-18

Abstract excerpt

<h4>ABSTRACT</h4> Thioesterase superfamily member 1 (Them1; synonyms Acyl-CoA thioesterase 11 (Acot11) and steroidogenic acute regulatory protein-related lipid transfer (START) domain 14 (StarD14) is a long chain acyl-CoA thioesterase comprising two N-terminal hot-dog fold enzymatic domains linked to a C-terminal lipid-sensing START domain, which allosterically modulates enzymatic activity. Them1 is highly expres...

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Literature Corpus work: 0474cc60-3316-51c3-a9ff-da52554555a7
DOI: 10.1101/2022.10.15.512369

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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver diseaseDOI 10.1101/2022.10.15.512369Read

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