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Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defense

2025-07-26

Abstract excerpt

Mycobacterium tuberculosis (Mtb) must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrophages by ACOD1 mediated decarboxylation of aconitate, has direct antimicrobial activity, modulates inflammatory cytokines, and is required for resistance to M. tuberculosis (Mtb) infection. The role...

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Identifiers and source

Literature Corpus work
cc90b8ee-47aa-55e4-bc8f-92500ca5196b
DOI
10.1101/2025.07.23.664455
Open publication

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Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defenseDOI 10.1101/2025.07.23.664455
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