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Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling

15 Jun 2023

Abstract excerpt

Cell migration through 3D environments is essential to development, disease, and regeneration processes. Conceptual models of migration have been developed primarily on the basis of 2D cell behaviors, but a general understanding of 3D cell migration is still lacking due to the added complexity of the extracellular matrix. Here, using a multiplexed biophysical imaging approach for single-cell analysis of human...

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PMID: 37321214
DOI: 10.1016/j.devcel.2023.05.013

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