Article
Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015
Kukat Christian, Davies Karen M, Wurm Christian A, Spåhr Henrik, Bonekamp Nina A, Kühl Inge, Joos Friederike, Polosa Paola Loguercio, Park Chan Bae, Posse Viktor, Falkenberg Maria, Jakobs Stefan, Kühlbrandt Werner, Larsson Nils-Göran
Abstract excerpt
Mammalian mitochondrial DNA (mtDNA) is packaged by mitochondrial transcription factor A (TFAM) into mitochondrial nucleoids that are of key importance in controlling the transmission and expression of mtDNA. Nucleoid ultrastructure is poorly defined, and therefore we used a combination of biochemistry, superresolution microscopy, and electron microscopy to show that mitochondrial nucleoids have an irregular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.