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Radiation-induced impacts on mitochondrial DNA and the transgenerational genomic instability

1 Feb 2025

Abstract excerpt

BACKGROUND: Mitochondrial genomes are dynamically evolving and are shaped by somatic mutation and selection throughout the female germline. In this study, we investigated the radiation-induced impacts on mitochondrial DNA in vitro and in vivo, as well as the transgenerational inheritance. METHODS: Human cervical cancer HeLa cells and telomerase-immortalized normal fibroblast BJ1-hTERT cells were exposed to X-rays...

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PMID: 39914081
DOI: 10.1016/j.envint.2025.109315

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