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Article

Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.

Nature structural & molecular biology - 1 Mar 2021

Li Sisi, Xie Tian, Liu Peng, Wang Lei, Gong Xin

Abstract excerpt

Human serine palmitoyltransferase (SPT) complex catalyzes the initial and rate-limiting step in the de novo biosynthesis of all sphingolipids. ORMDLs regulate SPT function, with human ORMDL3 being related to asthma. Here we report three high-resolution cryo-EM structures: the human SPT complex, composed of SPTLC1, SPTLC2 and SPTssa; the SPT-ORMDL3 complex; and the SPT-ORMDL3 complex bound to two substrates,...

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PMID: 33558762
DOI: 10.1038/s41594-020-00553-7

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