Article

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical models

2021-06-14

Abstract excerpt

Cholesterol esterification proteins Sterol-O acyltransferases (SOAT) 1 and 2 are emerging prognostic markers in many cancers. These enzymes utilise fatty acids conjugated to coenzyme A to esterify cholesterol. Cholesterol esterification is tightly regulated and enables formation of lipid droplets that act as storage organelles for lipid soluble vitamins and minerals, and as cholesterol reservoirs. In cancer, this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9549f55b-d4ae-53e1-8db7-5028e7821335
DOI: 10.1101/2021.06.12.448188

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pharmacologic and genetic inhibition of cholesterol esterification reduces tumour burden: a pan-cancer systematic review and meta-analysis of preclinical modelsDOI 10.1101/2021.06.12.448188Read

Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway.Semantic proximity Read

Cholesterol esterification blockade boosts immunotherapy and reduces cancer relapseSemantic proximity Read

Bilayer Forming Phospholipids as Targets for Cancer TherapySemantic proximity Read

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance.Semantic proximity Read

Targeting SOAT1 inhibits the progression of esophageal squamous cell carcinoma via ferroptosisSemantic proximity Read

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer InterventionsSemantic proximity Read

Correlation of cholesteryl ester metabolism to pathogenesis, progression and disparities in colorectal CancerSemantic proximity Read

Lipid-rich ascites reprograms T cell lipid metabolic transcriptome to drive dysfunctionSemantic proximity Read

SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic AdenocarcinomaSemantic proximity Read

Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindranceSemantic proximity Read

Molecular Targeting of Acid Ceramidase: Implications to Cancer TherapySemantic proximity Read

Targeting squalene epoxidase in the treatment of metabolic-related diseases: current research and future directionsSemantic proximity Read