LOCATE: using Long-read to Characterize All Transposable Elements

Abstract excerpt

Transposons constitute ~45% of the human genome, driving gene evolution and contributing to disease, but their repetitive nature complicates the identification of new insertions. We present LOCATE (Long-read to Characterize All Transposable Elements), an algorithm using long-read sequencing to detect and assemble transposon insertions. LOCATE outperforms existing tools on simulated datasets and achieves the best p...

Topics

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• DNA Transposable Elements
• Gene Rearrangement
• Genome, Human
• Genomics
• Molecular Sequence Annotation
• Mutagenesis, Insertional
• Pseudogenes
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

cabd2186-a23c-5ab2-8160-2ec150a8039d

DOI

10.1101/2025.02.26.640385