Article
Mobile element scanning (ME-Scan) by targeted high-throughput sequencing.
BMC genomics - 30 Jun 2010
Witherspoon David J, Xing Jinchuan, Zhang Yuhua, Watkins W Scott, Batzer Mark A, Jorde Lynn B
Abstract excerpt
BACKGROUND: Mobile elements (MEs) are diverse, common and dynamic inhabitants of nearly all genomes. ME transposition generates a steady stream of polymorphic genetic markers, deleterious and adaptive mutations, and substrates for further genomic rearrangements. Research on the impacts, population dynamics, and evolution of MEs is constrained by the difficulty of ascertaining rare polymorphic ME insertions that...
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