Article

Localized assembly for long reads enables genome-wide analysis of repetitive regions at single-base resolution in human genomes

2022-12-03

Abstract excerpt

<h4>Background</h4> Long-read sequencing technologies have the potential to overcome the limitations of short reads and provide a comprehensive picture of the human genome. However, it remains hard to characterize repetitive sequences by reconstructing genomic structures at high resolution solely from long reads. Here, we developed a localized assembly method (LoMA) that constructs highly accurate consensus seque...

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Literature Corpus work: 0d05a361-0ba1-5dcc-9d24-8c0db43d80a1
DOI: 10.1101/2022.12.02.518938

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