Article

Localized assembly for long reads enables genome-wide analysis of repetitive regions at single-base resolution in human genomes

2022-12-05

Abstract excerpt

<h4>Background: </h4> Long-read sequencing technologies have the potential to overcome the limitations of short reads and provide a comprehensive picture of the human genome. However, it remains hard to characterize repetitive sequences by reconstructing genomic structures at high resolution solely from long reads. Here, we developed a localized assembly method (LoMA) that constructs highly accurate consensus sequ...

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Literature Corpus work: 63255006-b857-54d8-918d-9bec8f7a0f15
DOI: 10.21203/rs.3.rs-2327629/v1

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