Article

A High-Fidelity Patient-Derived Organoid Platform Recapitulates the Dynamic Metabolic Landscape of Cisplatin Tolerance in Mesothelioma

2026-04-14

Abstract excerpt

<h4>Background: </h4> Pleural mesothelioma (PM) is characterised by often rapid therapeutic failure and chemotherapy resistance. While terminal resistance is well-studied, the initial transition into a drug-tolerant persister (DTP) state remains poorly understood. <h4>Methods:</h4> We established patient-derived organoids (PDOs) from malignant pleural effusions to model this transition. Cisplatin-tolerant lines we...

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Literature Corpus work: cabba31a-8236-590b-9a12-3b623dfb5c0a
DOI: 10.20944/preprints202604.0904.v1

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