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Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect

5 Apr 2024

Abstract excerpt

Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...

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Share to Bladder and Urothelial Cancer Treatments
Share to Cancer, Hypoxia, and Metabolism
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PMID: 38611096
DOI: 10.3390/cancers16071418

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