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Article

Validation of chemoresistance phenotypes in pleural mesothelioma across 2D, 3D, and in vivo models.

Scientific reports - 11 Feb 2026

Shi Huaikai, Selvamani Sakthi Priya, Zelei Richard, Zhuang Ling, Wang Dongwei, Johnson Ben, Dharwal Vivek, Xu Duo, Wang Yiwei, Rutland Tristan, Klebe Sonja, Kao Steven, Linton Anthony, Hosseini-Beheshti Elham, Cheng Yuen Yee

Abstract excerpt

Pleural mesothelioma (PM) is a highly aggressive cancer with limited treatment efficacy and poor prognosis. Conventional two-dimensional (2D) culture models fail to replicate the tumour microenvironment (TME), limiting their translational relevance. Here, we establish a three-dimensional (3D) spheroid model to investigate chemotherapy resistance across different PM subtypes. Compared to 2D cultures, 3D spheroids...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41673140
DOI: 10.1038/s41598-026-38692-4
PMCID: PMC12972125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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