Article

Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer

2023-02-21

Abstract excerpt

Sarcomatoid Urothelial Bladder Cancer (SARC) is a rare and aggressive histological subtype of bladder cancer for which therapeutic options are limited and experimental models are lacking. Here, we report the establishment of the first long-term 3D organoid-like model derived from a SARC patient ( SarBC-01 ). SarBC-01 emulates aggressive morphological and phenotypical features of SARC and harbor somatic mutations...

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Literature Corpus work: bbbcd5bf-4ffb-59ae-998c-3e6cb2d5e903
DOI: 10.1101/2023.02.20.528313

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