Article

Reprogramming of Osimertinib-Resistant EGFR-mutant NSCLC: The Pyruvate-Acetaldehyde-Acetate Pathway As a Key Driver of Resistance

2025-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Osimertinib (Osi) resistance remains a significant challenge in EGFR mutant non-small-cell lung cancer (NSCLC). This study investigates the metabolic reprogramming associated with Osi resistance, identifying key metabolic vulnerabilities that may be targeted for therapeutic intervention. Employing the EGFR-mutant H1975 parental (Par) cell line and its Osi-resistant (OsiR) counterpart, we integra...

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Literature Corpus work: 1f3b2bd8-d78c-50f5-af55-0435ee10221e
DOI: 10.1101/2025.06.27.661913

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